Immuno-Oncology
Immuno-oncology focuses on harnessing the body’s immune system to combat cancer. It has given rise to groundbreaking immunotherapies that have transformed cancer treatment. This approach is underpinned by genetic processes and cellular machinery.
In recent years, NGS technologies have been used to study how tumors adapt to evade the immune system and to analyze factors influencing responses to immunotherapy.
Drug Development
NGS and Microarray data are highly informative throughout the drug development process, including target discovery, target validation, preclinical and clinical development. With these methods, researchers can:
- Identify potential therapeutic drug targets and validate their potential by generating a comprehensive catalog of rare and common genetic variants.
- Evaluate the effectiveness of therapeutics by profiling the genetic mutations of patients.
- Detect, classify, predict medication responses, and provide prognoses by discovering and profiling molecular biomarkers.
- Deliver personalized care and targeted therapies based on individual genomic information, particularly for individuals with cancer or rare diseases.
Cancer Research
Cancer originates from DNA sequence changes in cancer cells. Next-Generation Sequencing (NGS) in cancer research has offered a comprehensive view of the cancer genome.
NGS has significantly expanded our understanding of oncogenic genetic changes, including point mutations, insertions, deletions, copy number variations, and structural variations. It also aids in discovering new oncogenes and uncovering the molecular mechanisms behind cancer development, spread, complexity, and diversity. This information informs therapeutic, diagnostic, and preventive strategies.
Rare and Complex Diseases
Complex diseases result from a mix of genetic and environmental factors. They often involve multiple genes and don’t follow a simple inheritance pattern. Many disease-causing mutations are found in non-coding parts of the genome, making them harder to study.
Recent advances in NGS technology have made it easier to analyze these regions, speeding up research on complex diseases. Since 80% of rare diseases have a genetic basis, using Next-Generation Sequencing (NGS) can reveal the genetic causes, leading to quicker diagnoses and faster treatment for patients.
Request a service
If you are a customer or represent hospitals, clinics, research centers, or universities interested in our services, please complete our contact form, and we will reach out to you.